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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346464
Species: Homo sapiens
RGD Object: Gene
Symbol: H2AX
Name: H2A.X variant histone
Acc ID: CHEBI:50131
Term: 5-aza-2'-deoxycytidine
Definition: A 2'-deoxyribonucleoside that has formula C8H12N4O4.
Chemical ID: MESH:C014347
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2AXaffects localizationEXP 6480464CTDDecitabine affects the localization of H2AX proteinPMID:17991895
H2AXincreases expressionEXP 6480464CTDDecitabine results in increased expression of H2AX proteinPMID:17991895 PMID:18223691
H2AXincreases phosphorylationEXP 6480464CTDDecitabine results in increased phosphorylation of H2AX proteinPMID:19215824 PMID:19732952
H2AXmultiple interactionsEXP 6480464CTDATM protein affects the reaction [Decitabine results in increased expression of H2AX protein]; DNMT1 protein affects the reaction [Decitabine results in increased expression of H2AX protein]; pifithrin inhibits the reaction [Decitabine results in increased phosphorylation of H2AX protein]; Wortmannin inhibits the reaction [Decitabine results in increased expression of H2AX protein]PMID:17991895 PMID:19732952
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