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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346464
Species: Homo sapiens
RGD Object: Gene
Symbol: H2AX
Name: H2A.X variant histone
Acc ID: CHEBI:40303
Term: lovastatin
Definition: A fatty acid ester that is mevastatin carrying an additional methyl group on the carbobicyclic skeleton. It is used in as an anticholesteremic drug and has been found in fungal species such as Aspergillus terreus and Pleurotus ostreatus (oyster mushroom).
Chemical ID: MESH:D008148
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
H2AXmultiple interactionsEXP 6480464CTDLovastatin inhibits the reaction [Cisplatin results in increased phosphorylation of H2AX protein]PMID:21356574
H2AXmultiple interactionsISOH2ax (Mus musculus)6480464CTDLovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form]; Lovastatin inhibits the reaction [Doxorubicin results in increased expression of H2AX protein modified form]; Lovastatin inhibits the reaction [Doxorubicin results in increased phosphorylation of H2AX protein]PMID:22712078 PMID:26739623 PMID:28710503
H2AXmultiple interactionsISOH2ax (Rattus norvegicus)6480464CTDLovastatin inhibits the reaction [Cisplatin results in increased expression of H2AX protein modified form]PMID:26739623
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