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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1346235
Species: Homo sapiens
RGD Object: Gene
Symbol: NFATC1
Name: nuclear factor of activated T cells 1
Acc ID: CHEBI:4031
Term: cyclosporin A
Definition: A cyclic nonribosomal peptide of eleven amino acids; an immunosuppressant drug widely used in post-allogeneic organ transplant to reduce the activity of the patient's immune system, and therefore the risk of organ rejection. Also causes reversible inhibition of immunocompetent lymphocytes in the G0- and G1-phase of the cell cycle.
Chemical ID: MESH:D016572
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NFATC1decreases expressionEXP 6480464CTDCyclosporine results in decreased expression of NFATC1 proteinPMID:24244623
NFATC1multiple interactionsEXP 6480464CTD[Cyclosporine co-treated with NGF protein] affects the localization of NFATC1 protein; [Tetradecanoylphorbol Acetate co-treated with Calcimycin] inhibits the reaction [Cyclosporine results in decreased expression of NFATC1 protein]; Cyclosporine affects the localization of and results in decreased activity of NFATC1 protein; Cyclosporine inhibits the reaction [Oxygen deficiency affects the localization of NFATC1 protein]; Cyclosporine inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of NFATC1 protein]PMID:19028555 PMID:24244623
NFATC1multiple interactionsISONfatc1 (Rattus norvegicus)6480464CTDCyclosporine inhibits the reaction [Isoproterenol affects the localization of NFATC1 protein]; Cyclosporine inhibits the reaction [Phenylephrine results in increased localization of and results in increased activity of NFATC1 protein]PMID:11435416 PMID:19349967
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