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GENE - TERM ANNOTATION REPORT

RGD ID: 1346162
Species: Homo sapiens
RGD Object: Gene
Symbol: GNB3
Name: G protein subunit beta 3
Acc ID: GO:0005834
Term: heterotrimeric G-protein complex
Definition: Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
Definition Source(s): ISBN:0198547684
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GNB3part_ofIEAUniProtKB:Q61011 or ensembl:ENSMUSP00000024206150520179Ensembl GO_REF:0000107
GNB3part_ofIBAFB:FBgn0001105 or FB:FBgn0004623 or MGI:104581 or MGI:95781 or MGI:95785 or PANTHER:PTN000457487 or PomBase:SPBC32H8.07 or Gnb1 (Rattus norvegicus) or SGD:S000005738 or TAIR:locus:2139489 or UniProtKB:P11017 or UniProtKB:P62871 or UniProtKB:P62873 or dictyBase:DDB_G0277143150520179GO_Central GO_REF:0000033
GNB3part_ofIEAPANTHER:PTHR19850:SF31150520179TreeGrafter GO_REF:0000118
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