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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345848
Species: Homo sapiens
RGD Object: Gene
Symbol: MMP3
Name: matrix metallopeptidase 3
Acc ID: CHEBI:90695
Term: anthra[1,9-cd]pyrazol-6(2H)-one
Definition: A member of the class of anthrapyrazoles that is anthra[1,9-cd]pyrazole substituted at position 6 by an oxo group. An inhibitor of c-Jun N-terminal kinase.
Chemical ID: MESH:C432165
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MMP3multiple interactionsEXP 6480464CTDpyrazolanthrone inhibits the reaction [2,2',4,6,6'-pentachlorobiphenyl results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [Citrinin results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [IL1A protein results in increased expression of MMP3 mRNA]; pyrazolanthrone inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP3 protein]PMID:12832416 PMID:16778083 PMID:19361540 PMID:20004183
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