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GENE - TERM ANNOTATION REPORT

RGD ID: 1345586
Species: Homo sapiens
RGD Object: Gene
Symbol: F7
Name: coagulation factor VII
Acc ID: HP:0008321
Term: Reduced factor X activity
Definition: Reduced activity of coagulation factor X. The extrinsic and intrinsic pathways converge at factor X (fX). The extrinsic pathway activates fX by means of d factor VII with its cofactor, tissue factor. The intrinsic pathway activates fX by means of the tenase complex (Ca2+ and factors VIIIa, IXa and X) on the surface of activated platelets. Factor Xa in turn activates prothrombin (factor II) to thrombin (factor IIa).
Definition Source(s): https://orcid.org/0000-0002-0736-9199
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

 
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

 
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

 
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

 
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

 
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

 
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

 
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

 
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

 
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

 
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

 
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

PMID:25741868 PMID:34355501
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

PMID:25741868 PMID:34355501
F7 IAGP (Homo sapiens)8554872ClinVarClinVar Annotator: match by term: Factor X deficiency

PMID:10984565 PMID:12181036 PMID:25741868
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