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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345576
Species: Homo sapiens
RGD Object: Gene
Symbol: DUSP5
Name: dual specificity phosphatase 5
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
DUSP5decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of DUSP5 mRNAPMID:12377990 PMID:19619570 PMID:20106945 PMID:21632981
DUSP5multiple interactionsEXP 6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of DUSP5 mRNA; [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of DUSP5 mRNA; [Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of DUSP5 protein; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of DUSP5 mRNA]; alpha-naphthoflavone inhibits the reaction [[Tetrachlorodibenzodioxin co-treated with Oxygen deficiency] results in decreased expression of DUSP5 protein]PMID:19578757 PMID:19619570
DUSP5decreases expressionISODusp5 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of DUSP5 mRNAPMID:19933214
DUSP5increases expressionISODusp5 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in increased expression of DUSP5 mRNAPMID:33387578
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