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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345145
Species: Homo sapiens
RGD Object: Gene
Symbol: PML
Name: PML nuclear body scaffold
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PMLaffects expressionISOPml (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of PML mRNAPMID:21570461
PMLincreases expressionISOPml (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of PML mRNAPMID:19933214 PMID:21889950
PMLmultiple interactionsISOPml (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with 2,4,5,2',4',5'-hexachlorobiphenyl co-treated with Diethylhexyl Phthalate co-treated with bisphenol A] results in decreased expression of PML mRNA; [TIPARP gene mutant form results in increased susceptibility to Tetrachlorodibenzodioxin] which results in increased expression of PML mRNAPMID:25975270 PMID:28433925
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