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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345145
Species: Homo sapiens
RGD Object: Gene
Symbol: PML
Name: PML nuclear body scaffold
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PMLincreases expressionEXP 6480464CTDresveratrol results in increased expression of PML mRNAPMID:25436977
PMLmultiple interactionsEXP 6480464CTD[Plant Extracts co-treated with Resveratrol] results in decreased expression of PML mRNA; BCL2 protein inhibits the reaction [Resveratrol promotes the reaction [PML protein binds to CREBBP protein]]; BCL2 protein inhibits the reaction [Resveratrol promotes the reaction [PML protein binds to DAXX protein]]; BCL2 protein inhibits the reaction [Resveratrol promotes the reaction [PML protein binds to SP100 protein]]; BCL2 protein inhibits the reaction [Resveratrol promotes the reaction [PML protein binds to SUMO1 protein]]; BCL2 protein inhibits the reaction [Resveratrol promotes the reaction [PML protein binds to TP53 protein]]; Resveratrol promotes the reaction [PML protein binds to CREBBP protein]; Resveratrol promotes the reaction [PML protein binds to DAXX protein]; Resveratrol promotes the reaction [PML protein binds to SP100 protein]; Resveratrol promotes the reaction [PML protein binds to SUMO1 protein]; Resveratrol promotes the reaction [PML protein binds to TP53 protein]; Resveratrol promotes the reaction [TP53 protein binds to PML protein binds to CREBBP protein]PMID:19631782 PMID:23557933
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