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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345118
Species: Homo sapiens
RGD Object: Gene
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
Acc ID: CHEBI:88217
Term: N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine
Definition: An N-substituted diamine that is ethylenediamine in which the four amino hydrogens are replaced by 2-pyridylmethyl groups.
Chemical ID: MESH:C044387
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PARP1decreases activityEXP 6480464CTDN,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine results in decreased activity of PARP1 proteinPMID:24275069
PARP1multiple interactionsEXP 6480464CTDN,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine affects the reaction [chromium hexavalent ion results in increased cleavage of PARP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Hydrogen Peroxide results in increased activity of PARP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc binds to PARP1 protein]PMID:15966574 PMID:24275069 PMID:33645215
PARP1multiple interactionsISOParp1 (Mus musculus)6480464CTDN,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [zinc chloride results in increased expression of PARP1 protein]PMID:22253048
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