GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PARP1 | multiple interactions | EXP | | 6480464 | CTD | [Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of PARP1 protein; [Arachidonic Acid co-treated with Iron] results in increased expression of PARP1 protein modified form; [ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased expression of SIRT1 protein]; PARP1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Plant Extracts inhibits the reaction [[Arachidonic Acid co-treated with Iron] results in increased expression of PARP1 protein modified form]; Rifampin inhibits the reaction [[Acetaminophen co-treated with [ferric nitrate results in increased abundance of Iron]] results in increased cleavage of PARP1 protein]; SIRT1 protein affects the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in decreased expression of PARP1 protein] | PMID:30626086 PMID:31678598 PMID:34826546 | | ||||||||||||||||||||||
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