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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345118
Species: Homo sapiens
RGD Object: Gene
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
Acc ID: CHEBI:70436
Term: platycodin D
Definition: A triterpenoid saponin that has formula C57H92O28.
Chemical ID: MESH:C108953
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PARP1increases activityEXP 6480464CTDplatycodin D results in increased activity of PARP1 proteinPMID:18804340 PMID:20412017
PARP1increases cleavageEXP 6480464CTDplatycodin D results in increased cleavage of PARP1 proteinPMID:23236765 PMID:24048756 PMID:24641402
PARP1multiple interactionsEXP 6480464CTD[platycodin D co-treated with Imatinib Mesylate] results in increased cleavage of and results in decreased expression of PARP1 proteinPMID:29552859
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