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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345118
Species: Homo sapiens
RGD Object: Gene
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
Acc ID: CHEBI:46666
Term: crocidolite asbestos
Definition: null
Chemical ID: MESH:D017638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PARP1decreases expressionEXP 6480464CTDAsbestos, Crocidolite results in decreased expression of PARP1 mRNA; Asbestos, Crocidolite results in decreased expression of PARP1 proteinPMID:32006662
PARP1increases cleavageEXP 6480464CTDAsbestos, Crocidolite results in increased cleavage of PARP1 proteinPMID:17191120 PMID:19783790
PARP1increases expressionEXP 6480464CTDAsbestos, Crocidolite results in increased expression of PARP1 mRNAPMID:20616036
PARP1multiple interactionsEXP 6480464CTD3-aminobenzamide inhibits the reaction [Asbestos, Crocidolite results in increased activity of PARP1 protein]; Asbestos, Crocidolite results in increased expression of and results in increased activity of PARP1 proteinPMID:20616036 PMID:21543585
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