Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345118
Species: Homo sapiens
RGD Object: Gene
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
Acc ID: CHEBI:40071
Term: 4-amino-1,8-naphthalimide
Definition: A benzoisoquinoline that has formula C12H8N2O2.
Chemical ID: MESH:C086538
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PARP1decreases expressionEXP 6480464CTD4-amino-1,8-naphthalimide results in decreased expression of PARP1 proteinPMID:25499136
PARP1multiple interactionsEXP 6480464CTD4-amino-1,8-naphthalimide inhibits the reaction [Doxorubicin results in increased activity of PARP1 protein]PMID:15456408
PARP1decreases activityISOParp1 (Mus musculus)6480464CTD4-amino-1,8-naphthalimide results in decreased activity of PARP1 proteinPMID:16556909
PARP1multiple interactionsISOParp1 (Mus musculus)6480464CTDATM protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of ATM protein]; PARP1 protein affects the reaction [4-amino-1,8-naphthalimide results in increased phosphorylation of CHEK2 protein]; PRKDC protein affects the reaction [4-amino-1,8-naphthalimide results in decreased activity of PARP1 protein]PMID:16556909
Go Back to source page   Continue to Ontology report