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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345118
Species: Homo sapiens
RGD Object: Gene
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
Acc ID: CHEBI:34631
Term: chlorpyrifos
Definition: An organic thiophosphate that is O,O-diethyl hydrogen phosphorothioate in which the hydrogen of the hydroxy group has been replaced by a 3,5,6-trichloropyridin-2-yl group.
Chemical ID: MESH:D004390
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PARP1increases cleavageEXP 6480464CTDChlorpyrifos results in increased cleavage of PARP1 proteinPMID:24793810
PARP1increases expressionEXP 6480464CTDChlorpyrifos results in increased expression of PARP1 mRNA; Chlorpyrifos results in increased expression of PARP1 protein; Chlorpyrifos results in increased expression of PARP1 protein modified formPMID:23416140 PMID:28887667
PARP1increases cleavageISOParp1 (Mus musculus)6480464CTDChlorpyrifos results in increased cleavage of PARP1 proteinPMID:34289071 PMID:36252918
PARP1increases cleavageISOParp1 (Rattus norvegicus)6480464CTDChlorpyrifos results in increased cleavage of PARP1 proteinPMID:22714038 PMID:29859868
PARP1increases expressionISOParp1 (Rattus norvegicus)6480464CTDChlorpyrifos results in increased expression of PARP1 mRNA; Chlorpyrifos results in increased expression of PARP1 proteinPMID:33908150
PARP1multiple interactionsISOParp1 (Rattus norvegicus)6480464CTD[Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 mRNA; [Hesperidin co-treated with Chlorpyrifos] results in increased expression of PARP1 protein; Acetylcysteine inhibits the reaction [Chlorpyrifos results in increased cleavage of PARP1 protein]; STAT1 protein affects the reaction [Chlorpyrifos results in increased cleavage of PARP1 protein]PMID:22714038 PMID:29859868 PMID:33908150
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