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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345118
Species: Homo sapiens
RGD Object: Gene
Symbol: PARP1
Name: poly(ADP-ribose) polymerase 1
Acc ID: CHEBI:30185
Term: zinc(0)
Definition: An elemental zinc that has formula Zn.
Chemical ID: MESH:D015032
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PARP1affects bindingEXP 6480464CTDPARP1 protein binds to Zinc; PARP1 protein modified form binds to Zinc; Zinc binds to PARP1 proteinPMID:24275069 PMID:25549802 PMID:31152818
PARP1increases cleavageEXP 6480464CTDZinc deficiency results in increased cleavage of PARP1 protein; Zinc results in increased cleavage of PARP1 proteinPMID:16472982 PMID:16799065 PMID:23377617 PMID:28507149
PARP1increases foldingEXP 6480464CTDZinc results in increased folding of PARP1 proteinPMID:31152818
PARP1multiple interactionsEXP 6480464CTD[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein; Cisplatin inhibits the reaction [Zinc binds to PARP1 protein]; Dopamine promotes the reaction [Zinc deficiency results in increased cleavage of PARP1 protein]; imidazolium-bis(imidazole)dimethylsulfoxideimidazotetrachlororuthenate(III) inhibits the reaction [Zinc binds to PARP1 protein]; linsidomine inhibits the reaction [PARP1 protein binds to Zinc]; Luteolin inhibits the reaction [[Lead co-treated with Cadmium co-treated with Mercury co-treated with Copper co-treated with Zinc co-treated with Manganese co-treated with Chromium co-treated with Nickel] results in increased cleavage of PARP1 protein]; N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine inhibits the reaction [Zinc binds to PARP1 protein]; Organogold Compounds inhibits the reaction [Zinc binds to PARP1 protein]; RAPTA-T inhibits the reaction [Zinc binds to PARP1 protein]; sodium arsenite inhibits the reaction [PARP1 protein binds to Zinc]; sodium arsenite inhibits the reaction [Zinc binds to PARP1 protein]; Uric Acid inhibits the reaction [sodium arsenite inhibits the reaction [PARP1 protein binds to Zinc]]; Zinc affects the reaction [chromium hexavalent ion results in increased cleavage of PARP1 protein]; Zinc binds to and results in increased activity of PARP1 protein; Zinc deficiency promotes the reaction [Dopamine results in increased cleavage of PARP1 protein]; Zinc inhibits the reaction [arsenite results in decreased activity of PARP1 protein]; Zinc inhibits the reaction [monomethylarsonous acid results in decreased activity of PARP1 protein]; Zinc inhibits the reaction [sodium arsenite inhibits the reaction [Zinc binds to PARP1 protein]]; Zinc inhibits the reaction [sodium arsenite results in decreased activity of PARP1 protein]PMID:15966574 PMID:18707137 PMID:21370912 PMID:21925530 PMID:23377617 PMID:24275069 PMID:28552776 PMID:29115570 PMID:31152818
PARP1decreases expressionISOParp1 (Rattus norvegicus)6480464CTDZinc results in decreased expression of PARP1 proteinPMID:16799065
PARP1multiple interactionsISOParp1 (Mus musculus)6480464CTDPARP1 protein affects the reaction [Zinc results in decreased abundance of Adenosine Triphosphate]; PARP1 protein affects the reaction [Zinc results in decreased uptake of Excitatory Amino Acid Agents]; Zinc inhibits the reaction [sodium arsenite results in decreased activity of PARP1 protein]PMID:17728843 PMID:26443841
PARP1multiple interactionsISOParp1 (Rattus norvegicus)6480464CTD6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid inhibits the reaction [Zinc results in decreased expression of PARP1 protein]; [[sodium arsenite results in increased abundance of Arsenic] which co-treated with Zinc deficiency] results in increased cleavage of PARP1 protein; Metipranolol inhibits the reaction [Zinc results in decreased expression of PARP1 protein]PMID:16799065 PMID:31542844
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