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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:67040
Term: S-adenosyl-L-methioninate
Definition: A sulfonium betaine that is a conjugate base of S-adenosyl-L-methionine obtained by the deprotonation of the carboxy group.
Chemical ID: MESH:D012436
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1decreases activityEXP 6480464CTDS-Adenosylmethionine results in decreased activity of CYP2E1 proteinPMID:15763544
CYP2E1decreases activityISOCyp2e1 (Rattus norvegicus)6480464CTDS-Adenosylmethionine results in decreased activity of CYP2E1 proteinPMID:15763544
CYP2E1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTDS-Adenosylmethionine inhibits the reaction [Acetaminophen results in decreased expression of CYP2E1 protein]; S-Adenosylmethionine promotes the reaction [Carbon Tetrachloride results in decreased expression of and results in decreased activity of CYP2E1 protein]PMID:15983038 PMID:22683606
CYP2E1multiple interactionsISOCyp2e1 (Rattus norvegicus)6480464CTDS-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of 4-nitrophenol]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Ethanol]PMID:15763544
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