GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CYP2E1 | affects metabolic processing | EXP | | 6480464 | CTD | CYP2E1 protein affects the metabolism of Dimethylnitrosamine | PMID:16235733 PMID:2655891 | CYP2E1 | decreases activity | EXP | | 6480464 | CTD | Dimethylnitrosamine results in decreased activity of CYP2E1 protein | PMID:24561005 | CYP2E1 | decreases methylation | EXP | | 6480464 | CTD | CYP2E1 protein results in decreased methylation of Dimethylnitrosamine | PMID:11181492 | CYP2E1 | increases metabolic processing | EXP | | 6480464 | CTD | CYP2E1 protein results in increased metabolism of Dimethylnitrosamine | PMID:12464242 PMID:15242818 PMID:35882637 | CYP2E1 | multiple interactions | EXP | | 6480464 | CTD | [[SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to Dimethylnitrosamine] which results in increased mutagenesis of HPRT1 gene; [CYP2E1 protein co-treated with POR protein co-treated with CYB5B protein] results in increased susceptibility to Dimethylnitrosamine; [SULT1A1 protein co-treated with CYP2E1 protein] results in increased susceptibility to Dimethylnitrosamine; [vinyl carbamate co-treated with NADP] inhibits the reaction [CYP2E1 protein results in decreased methylation of Dimethylnitrosamine]; CYP2E1 protein affects the metabolism of and results in increased activity of Dimethylnitrosamine; CYP2E1 protein results in increased metabolism of and results in increased activity of Dimethylnitrosamine; diallyl sulfone inhibits the reaction [CYP2E1 protein results in decreased methylation of Dimethylnitrosamine]; Dimethylnitrosamine inhibits the reaction [Carbon Tetrachloride inhibits the reaction [CYP2E1 protein results in increased oxidation of 4-nitrophenol]]; Dimethylnitrosamine inhibits the reaction [Carbon Tetrachloride results in increased degradation of CYP2E1 protein]; Ethanol affects the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; Ethanol promotes the reaction [CYP2E1 protein results in increased oxidation of Dimethylnitrosamine]; Lipopolysaccharides affects the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine] | PMID:11181492 PMID:11600130 PMID:11733072 PMID:11960914 PMID:16235733 PMID:27913846 PMID:8074729 PMID:8531136 | CYP2E1 | decreases expression | ISO | Cyp2e1 (Mus musculus) | 6480464 | CTD | Dimethylnitrosamine results in decreased expression of CYP2E1 mRNA | PMID:11356909 | CYP2E1 | decreases methylation | ISO | Cyp2e1 (Rattus norvegicus) | 6480464 | CTD | CYP2E1 protein results in decreased methylation of Dimethylnitrosamine | PMID:3113478 PMID:8194125 | CYP2E1 | increases metabolic processing | ISO | Cyp2e1 (Rattus norvegicus) | 6480464 | CTD | CYP2E1 protein results in increased metabolism of Dimethylnitrosamine | PMID:15763544 | CYP2E1 | multiple interactions | ISO | Cyp2e1 (Rattus norvegicus) | 6480464 | CTD | allyl sulfide inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine]; S-Adenosylmethionine inhibits the reaction [CYP2E1 protein results in increased metabolism of Dimethylnitrosamine] | PMID:15763544 PMID:8117321 | | ||||||||||||||||||||||
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