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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1345007
Species: Homo sapiens
RGD Object: Gene
Symbol: CYP2E1
Name: cytochrome P450 family 2 subfamily E member 1
Acc ID: CHEBI:16602
Term: trichloroethene
Definition: A member of the class of chloroethenes that is ethene substituted by chloro groups at positions 1, 1 and 2.
Chemical ID: MESH:D014241
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CYP2E1affects metabolic processingEXP 6480464CTDCYP2E1 protein affects the metabolism of TrichloroethylenePMID:17710613
CYP2E1affects response to substanceEXP 6480464CTDCYP2E1 protein affects the susceptibility to TrichloroethylenePMID:35763063
CYP2E1increases activityEXP 6480464CTDTrichloroethylene results in increased activity of CYP2E1 proteinPMID:17710613
CYP2E1increases metabolic processingEXP 6480464CTDCYP2E1 protein results in increased metabolism of TrichloroethylenePMID:10841534 PMID:18350910
CYP2E1increases oxidationEXP 6480464CTDCYP2E1 protein results in increased oxidation of TrichloroethylenePMID:1664256 PMID:29897530
CYP2E1increases response to substanceEXP 6480464CTDCYP2E1 gene polymorphism results in increased susceptibility to TrichloroethylenePMID:19351467
CYP2E1multiple interactionsEXP 6480464CTD[CYP2E1 protein results in increased oxidation of Trichloroethylene] which results in increased abundance of Trichloroacetic AcidPMID:29897530
CYP2E1affects metabolic processingISOCyp2e1 (Rattus norvegicus)6480464CTDCYP2E1 protein affects the metabolism of TrichloroethylenePMID:17710613 PMID:7871537
CYP2E1decreases expressionISOCyp2e1 (Rattus norvegicus)6480464CTDTrichloroethylene results in decreased expression of CYP2E1 mRNAPMID:33387578
CYP2E1increases activityISOCyp2e1 (Rattus norvegicus)6480464CTDTrichloroethylene results in increased activity of CYP2E1 proteinPMID:17710613 PMID:8620572
CYP2E1increases expressionISOCyp2e1 (Mus musculus)6480464CTDTrichloroethylene results in increased expression of CYP2E1 proteinPMID:10753203
CYP2E1increases expressionISOCyp2e1 (Rattus norvegicus)6480464CTDTrichloroethylene results in increased expression of CYP2E1 proteinPMID:8620572
CYP2E1increases metabolic processingISOCyp2e1 (Mus musculus)6480464CTDCYP2E1 protein results in increased metabolism of TrichloroethylenePMID:10774820 PMID:18565563 PMID:8461037
CYP2E1increases metabolic processingISOCyp2e1 (Rattus norvegicus)6480464CTDCYP2E1 protein results in increased metabolism of TrichloroethylenePMID:1739413 PMID:18249509 PMID:8461037
CYP2E1increases response to substanceISOCyp2e1 (Rattus norvegicus)6480464CTDCYP2E1 protein results in increased susceptibility to TrichloroethylenePMID:17433522
CYP2E1multiple interactionsISOCyp2e1 (Mus musculus)6480464CTD[diallyl disulfide results in decreased expression of CYP2E1 protein] which results in decreased metabolism of and results in decreased susceptibility to TrichloroethylenePMID:10774820
CYP2E1multiple interactionsISOCyp2e1 (Rattus norvegicus)6480464CTD1,2-dichloroethylene inhibits the reaction [CYP2E1 protein affects the metabolism of Trichloroethylene]; [CYP2E1 protein results in increased metabolism of Trichloroethylene] which results in increased chemical synthesis of Chloral Hydrate; CYP2E1 protein affects the reaction [Trichloroethylene results in increased metabolism of Toluene]; Trichloroethylene inhibits the reaction [Acetone results in increased activity of CYP2E1 protein]PMID:1739413 PMID:7871537 PMID:8620572 PMID:9851676
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