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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344671
Species: Homo sapiens
RGD Object: Gene
Symbol: TFF1
Name: trefoil factor 1
Acc ID: CHEBI:34027
Term: 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane
Definition: A diarylmethane that has formula C14H9Cl5.
Chemical ID: MESH:C016340
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TFF1increases expressionEXP 6480464CTDo,p'-DDT results in increased expression of TFF1 mRNAPMID:18700809 PMID:20206645 PMID:22609851 PMID:23478948 PMID:8968093
TFF1multiple interactionsEXP 6480464CTD2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]; Fulvestrant inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]; ICI 164384 inhibits the reaction [o,p'-DDT results in increased expression of TFF1 mRNA]PMID:18700809 PMID:20206645 PMID:8968093
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