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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344668
Species: Homo sapiens
RGD Object: Gene
Symbol: NAT1
Name: N-acetyltransferase 1
Acc ID: CHEBI:30753
Term: 4-aminobenzoic acid
Definition: An aminobenzoic acid in which the amino group is para to the carboxy group.
Chemical ID: MESH:D010129
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NAT1affects acetylationEXP 6480464CTDNAT1 protein affects the acetylation of 4-Aminobenzoic AcidPMID:29043425
NAT1increases acetylationEXP 6480464CTDNAT1 protein results in increased acetylation of 4-Aminobenzoic AcidPMID:11470991 PMID:15627487 PMID:15880531 PMID:16003948 PMID:23958860
NAT1increases metabolic processingEXP 6480464CTDNAT1 protein results in increased metabolism of 4-Aminobenzoic AcidPMID:30358977
NAT1multiple interactionsEXP 6480464CTDDehydroepiandrosterone Sulfate inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Dehydroepiandrosterone Sulfate promotes the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]; Pentachlorophenol inhibits the reaction [NAT1 protein results in increased acetylation of 4-Aminobenzoic Acid]PMID:11470991
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