Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344624
Species: Homo sapiens
RGD Object: Gene
Symbol: ABCC1
Name: ATP binding cassette subfamily C member 1 (ABCC1 blood group)
Acc ID: CHEBI:16325
Term: lithocholic acid
Definition: A monohydroxy-5beta-cholanic acid with a alpha-hydroxy substituent at position 3. It is a bile acid obtained from chenodeoxycholic acid by bacterial action.
Chemical ID: MESH:D008095
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ABCC1multiple interactionsEXP 6480464CTDLithocholic Acid inhibits the reaction [ABCC1 protein results in increased export of 2',7'-bis-(carboxypropyl)-5(6)-carboxyfluorescein]PMID:16101123
ABCC1increases expressionISOAbcc1 (Mus musculus)6480464CTDLithocholic Acid results in increased expression of ABCC1 mRNA; Lithocholic Acid results in increased expression of ABCC1 proteinPMID:18032408 PMID:20977460 PMID:23034213
ABCC1multiple interactionsISOAbcc1 (Mus musculus)6480464CTD[Lithocholic Acid co-treated with oltipraz] results in increased expression of ABCC1 protein; NFE2L2 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]; SMAD3 protein promotes the reaction [Lithocholic Acid results in increased expression of ABCC1 mRNA]PMID:18032408 PMID:20977460 PMID:23034213
Go Back to source page   Continue to Ontology report