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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344623
Species: Homo sapiens
RGD Object: Gene
Symbol: GSTA5
Name: glutathione S-transferase alpha 5
Acc ID: CHEBI:77323
Term: ethoxyquin
Definition: A quinoline that is 1,2-dihydroquinoline bearing three methyl substituents at position 2, 2 and 4 as well as an ethoxy substituent at position 6.
Chemical ID: MESH:D005015
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GSTA5increases activityISOGsta5 (Rattus norvegicus)6480464CTDEthoxyquin results in increased activity of GSTA5 proteinPMID:9328168
GSTA5increases expressionISOGsta5 (Rattus norvegicus)6480464CTDEthoxyquin results in increased expression of GSTA5 mRNA; Ethoxyquin results in increased expression of GSTA5 proteinPMID:1637297 PMID:19695238 PMID:9794803
GSTA5increases expressionISOGsta1 (Mus musculus)6480464CTDEthoxyquin results in increased expression of GSTA1 proteinPMID:11309284
GSTA5multiple interactionsISOGsta5 (Rattus norvegicus)6480464CTDEthoxyquin promotes the reaction [GSTA5 protein affects the metabolism of aflatoxin B1-2,3-oxide]; Ethoxyquin results in increased expression of and results in increased activity of GSTA5 proteinPMID:8198522
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