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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344540
Species: Homo sapiens
RGD Object: Gene
Symbol: IL1RN
Name: interleukin 1 receptor antagonist
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
IL1RNdecreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of IL1RN mRNAPMID:20106945 PMID:22262711
IL1RNincreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in increased expression of IL1RN mRNAPMID:19619570 PMID:22262711 PMID:28351761
IL1RNmultiple interactionsEXP 6480464CTD[Estradiol co-treated with Tetrachlorodibenzodioxin] results in decreased expression of IL1RN mRNA; alpha-naphthoflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of IL1RN mRNA]; IL1RN protein inhibits the reaction [[IL1B protein co-treated with Tetrachlorodibenzodioxin] results in increased expression of IL6 mRNA]PMID:19619570 PMID:20511231 PMID:22262711
IL1RNaffects expressionISOIl1rn (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin affects the expression of IL1RN mRNAPMID:22298810 PMID:34747641
IL1RNdecreases expressionISOIl1rn (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of IL1RN mRNAPMID:32553695
IL1RNincreases expressionISOIl1rn (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of IL1RN mRNAPMID:19770486
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