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GENE - TERM ANNOTATION REPORT

RGD ID: 1344478
Species: Homo sapiens
RGD Object: Gene
Symbol: HDAC8
Name: histone deacetylase 8
Acc ID: GO:0004407
Term: histone deacetylase activity
Definition: Catalysis of the reaction: histone N6-acetyl-L-lysine + H2O = histone L-lysine + acetate. This reaction represents the removal of an acetyl group from a histone, a class of proteins complexed to DNA in chromatin and chromosomes.
Definition Source(s): PMID:9893272, RHEA:58196
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
HDAC8enablesIBAFB:FBgn0015805 or FB:FBgn0025825 or FB:FBgn0026428 or FB:FBgn0029783 or MGI:108086 or MGI:1097691 or MGI:1333752 or MGI:2385849 or PANTHER:PTN008143312 or PomBase:SPAC3G9.07c or PomBase:SPBC36.05c or PomBase:SPBC800.03 or SGD:S000003162 or SGD:S000005274 or TAIR:locus:2120948 or TAIR:locus:2159461 or TAIR:locus:2162017 or UniProtKB:C8V606 or UniProtKB:D6XGM6 or UniProtKB:G5EB64 or UniProtKB:O15379 or UniProtKB:Q13547 or UniProtKB:Q586J9 or UniProtKB:Q8GXJ1 or UniProtKB:Q8RX28 or UniProtKB:Q92769 or UniProtKB:Q969S8 or UniProtKB:Q96DB2 or UniProtKB:Q9BY41 or UniProtKB:Q9NRC8 or UniProtKB:Q9UBN7 or WB:WBGene00001834 or dictyBase:DDB_G0270338150520179GO_Central GO_REF:0000033
HDAC8enablesIEAInterPro:IPR003084150520179InterPro GO_REF:0000002
HDAC8enablesTAS 150520179PINC PMID:10748112 PMID:12711221

PMID:10748112 PMID:12711221 Reactome:R-HSA-3782637
HDAC8enablesIEARHEA:58196150520179RHEA GO_REF:0000116
HDAC8enablesIDA 150520179UniProt PMID:28497810

PMID:28497810
HDAC8enablesIEAEC:3.5.1.98150520179UniProt GO_REF:0000003
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