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GENE - TERM ANNOTATION REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: DOID:9004484
Term: Sepsis
Definition: Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.
Definition Source(s): MESH:D018805
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNF ISOTnf (Rattus norvegicus)4144094RGDmRNA:increased expression:heart 
TNF ISOTnf (Rattus norvegicus)5147745RGD  
TNFtreatmentISOTnf (Mus musculus)14975262RGD  
TNFtreatmentISOTnf (Rattus norvegicus)7364867RGD  
TNF EXP 11554173CTDCTD Direct Evidence: marker/mechanismPMID:8741040 PMID:9806674 PMID:15489642
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