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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:78886
Term: 2-tert-butylhydroquinone
Definition: A member of the class of hydroquinones in which one of the ring hydrogens of hydroquinone is replaced by a tert-butyl group.
Chemical ID: MESH:C018855
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFmultiple interactionsEXP 6480464CTD2-tert-butylhydroquinone inhibits the reaction [TNF protein affects the localization of NFKBIA protein]; 2-tert-butylhydroquinone inhibits the reaction [TNF protein affects the localization of RELA protein]; 2-tert-butylhydroquinone inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]; 2-tert-butylhydroquinone inhibits the reaction [TNF protein results in increased expression of TNFAIP3 protein]PMID:35724838
TNFmultiple interactionsISOTnf (Mus musculus)6480464CTD2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of TNF mRNA]; 2-tert-butylhydroquinone inhibits the reaction [2,2-dichloroacetyl chloride results in increased expression of TNF protein]PMID:32073640
TNFmultiple interactionsISOTnf (Rattus norvegicus)6480464CTD2-tert-butylhydroquinone inhibits the reaction [Cisplatin results in increased expression of TNF mRNA]; 2-tert-butylhydroquinone inhibits the reaction [ferrous sulfate results in increased expression of TNF protein]PMID:28583816 PMID:32565124
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