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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344192
Species: Homo sapiens
RGD Object: Gene
Symbol: TNF
Name: tumor necrosis factor
Acc ID: CHEBI:479072
Term: 2-aminopurine
Definition: The parent compound of the 2-aminopurines, comprising a purine core carrying an amino substituent at the 2-position.
Chemical ID: MESH:D015075
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TNFmultiple interactionsISOTnf (Mus musculus)6480464CTD2-Aminopurine affects the reaction [LEP protein affects the expression of TNF mRNA]; 2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of ACP5 protein]; 2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of ATP6V0D2 protein]; 2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of CALCR protein]; 2-Aminopurine inhibits the reaction [[TNF protein co-treated with TNFSF11 protein] results in increased expression of MATK protein]; 2-Aminopurine inhibits the reaction [TNF protein affects the localization of NFATC1 protein]; 2-Aminopurine inhibits the reaction [TNF protein affects the localization of NFKB1 protein]; 2-Aminopurine inhibits the reaction [TNF protein affects the localization of RELA protein]; 2-Aminopurine inhibits the reaction [TNF protein promotes the reaction [TNFSF11 protein results in increased expression of FOS protein]]; 2-Aminopurine inhibits the reaction [TNF protein promotes the reaction [TNFSF11 protein results in increased expression of NFATC1 protein]]; 2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of EIF2AK2 protein]; 2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK1 protein]; 2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of MAPK3 protein]; 2-Aminopurine inhibits the reaction [TNF protein results in increased phosphorylation of NFKBIA protein]PMID:24150608 PMID:25739386
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