GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | TNF | increases expression | EXP | | 6480464 | CTD | Allopurinol results in increased expression of TNF mRNA | PMID:26641773 | TNF | multiple interactions | EXP | | 6480464 | CTD | Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased phosphorylation of RELA protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL17 protein]; Allopurinol inhibits the reaction [[IFNG protein co-treated with TNF protein] results in increased secretion of CCL22 protein]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL17 mRNA]; Allopurinol inhibits the reaction [TNF protein results in increased expression of CCL22 mRNA]; U 0126 inhibits the reaction [Allopurinol results in increased expression of TNF mRNA] | PMID:26641773 PMID:28949055 | TNF | increases chemical synthesis | ISO | Tnf (Mus musculus) | 6480464 | CTD | TNF protein results in increased chemical synthesis of Allopurinol | PMID:7695923 | TNF | multiple interactions | ISO | Tnf (Mus musculus) | 6480464 | CTD | [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of TNF mRNA; [1-Naphthylisothiocyanate co-treated with Allopurinol] results in increased expression of TNF protein | PMID:33749747 | TNF | multiple interactions | ISO | Tnf (Rattus norvegicus) | 6480464 | CTD | Allopurinol inhibits the reaction [Fructose results in increased expression of TNF protein] | PMID:22426011 | | ||||||||||||||||||||||
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