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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344163
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I3
Name: nuclear receptor subfamily 1 group I member 3
Acc ID: CHEBI:48347
Term: triclocarban
Definition: A member of the class of phenylureas that is urea substituted by a 4-chlorophenyl group and a 3,4-dichlorophenyl group at positions 1 and 3 respectively.
Chemical ID: MESH:C009540
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I3multiple interactionsEXP 6480464CTDNR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A1 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A3 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A4 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A6 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of UGT1A9 mRNA]PMID:22761658
NR1I3multiple interactionsISONr1i3 (Mus musculus)6480464CTDNR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 mRNA]; NR1I3 gene mutant form inhibits the reaction [triclocarban results in increased expression of CYP2B10 protein]PMID:22761658
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