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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344163
Species: Homo sapiens
RGD Object: Gene
Symbol: NR1I3
Name: nuclear receptor subfamily 1 group I member 3
Acc ID: CHEBI:34911
Term: permethrin
Definition: A cyclopropanecarboxylate ester in which the esterifying alcohol is 3-phenoxybenzyl alcohol and the cyclopropane ring is substituted with a 2,2-dichlorovinyl group and with gem-dimethyl groups.
Chemical ID: MESH:D026023
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
NR1I3affects bindingEXP 6480464CTDPermethrin binds to NR1I3 proteinPMID:31312845
NR1I3increases activityEXP 6480464CTDPermethrin results in increased activity of NR1I3 proteinPMID:21924250 PMID:26187274 PMID:28927721
NR1I3multiple interactionsEXP 6480464CTD[Permethrin co-treated with NR1I3 protein mutant form] results in increased expression of CYP2B6 mRNA; Permethrin binds to and results in increased activity of NR1I3 protein alternative form; Permethrin inhibits the reaction [ethyl (5-(diethylglycyl)-10,11-dihydro-5H-dibenzo(b,f)azepin-3-yl)carbamate results in decreased activity of NR1I3 protein]; Permethrin promotes the reaction [MED1 protein binds to NR1I3 protein alternative form]; Permethrin promotes the reaction [NCOA1 protein binds to NR1I3 protein alternative form]; Permethrin promotes the reaction [NCOA1 protein binds to NR1I3 protein]; Permethrin promotes the reaction [NCOA3 protein binds to NR1I3 protein]; Permethrin promotes the reaction [NR1I3 protein modified form binds to NCOA1 protein]PMID:21924250 PMID:31312845
NR1I3increases expressionISONr1i3 (Mus musculus)6480464CTDPermethrin results in increased expression of NR1I3 mRNAPMID:16929008
NR1I3multiple interactionsISONr1i3 (Rattus norvegicus)6480464CTDPermethrin binds to and results in increased activity of NR1I3 proteinPMID:31538121
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