GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | NR1I3 | multiple interactions | EXP | | 6480464 | CTD | [Estradiol co-treated with Progesterone] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased activity of NR1I3 protein]; [Progesterone co-treated with Estradiol] inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]; [Progesterone co-treated with Estradiol] inhibits the reaction [Phenobarbital results in increased activity of NR1I3 protein]; NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of G6PC1 mRNA]]; NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in decreased expression of SREBF1 mRNA]]; NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2B6 mRNA]]; NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime results in increased expression of CYP2C9 mRNA]]; NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in decreased expression of G6PC1 mRNA]]; NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in decreased expression of SREBF1 mRNA]]; NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in increased expression of CYP2B6 mRNA]]; NR1I3 mutant form inhibits the reaction [Progesterone inhibits the reaction [Phenobarbital results in increased expression of CYP2C9 mRNA]]; Progesterone inhibits the reaction [6-(4-chlorophenyl)imidazo(2,1-b)(1,3)thiazole-5-carbaldehyde O-(3,4-dichlorobenzyl)oxime promotes the reaction [[NR1I3 protein co-treated with FOXO1 protein co-treated with HNF4A protein co-treated with NCOA1 protein] binds to CYP2C9 promoter]]; Progesterone inhibits the reaction [Phenobarbital results in increased activity of NR1I3 protein] | PMID:21768169 | NR1I3 | decreases activity | ISO | Nr1i3 (Mus musculus) | 6480464 | CTD | Progesterone results in decreased activity of NR1I3 protein | PMID:11075820 | NR1I3 | multiple interactions | ISO | Nr1i3 (Mus musculus) | 6480464 | CTD | Estradiol inhibits the reaction [Progesterone results in decreased activity of NR1I3 protein]; Estrone inhibits the reaction [Progesterone results in decreased activity of NR1I3 protein] | PMID:11075820 | | ||||||||||||||||||||||
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