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GENE - TERM ANNOTATION REPORT

RGD ID: 1344051
Species: Homo sapiens
RGD Object: Gene
Symbol: MIR130B
Name: microRNA 130b
Acc ID: GO:0035195
Term: miRNA-mediated post-transcriptional gene silencing
Definition: A post-transcriptional gene silencing pathway in which regulatory microRNAs (miRNAs) elicit silencing of specific target genes. miRNAs are endogenous 21-24 nucleotide small RNAs processed from stem-loop RNA precursors (pre-miRNAs). Once incorporated into a RNA-induced silencing complex (RISC), miRNAs can downregulate protein production by either of two posttranscriptional mechanisms: endonucleolytic cleavage of the RNA (often mRNA) or mRNA translational repression, usually accompanied by poly-A tail shortening and subsequent degradation of the mRNA. miRNAs are present in all the animals and in plants, whereas siRNAs are present in lower animals and in plants.
Definition Source(s): GOC:aruk, GOC:bc, GOC:rl, PMID:14744438, PMID:15066275, PMID:15066283, PMID:23209154, PMID:23985560, PMID:28379604
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MIR130Binvolved_inIDA 150520179ARUK-UCL PMID:24498407 PMID:25802328 PMID:26501192 PMID:27364335 PMID:31512787

PMID:24498407 PMID:25802328 PMID:26501192 PMID:27364335 PMID:31512787
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