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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1344001
Species: Homo sapiens
RGD Object: Gene
Symbol: GDF15
Name: growth differentiation factor 15
Acc ID: CHEBI:28748
Term: doxorubicin
Definition: An anthracycline antibiotic that has formula C27H29NO11.
Chemical ID: MESH:D004317
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
GDF15decreases expressionEXP 6480464CTDDoxorubicin results in decreased expression of GDF15 mRNAPMID:16705698
GDF15decreases response to substanceEXP 6480464CTDGDF15 protein results in decreased susceptibility to DoxorubicinPMID:22615612
GDF15increases expressionEXP 6480464CTDDoxorubicin results in increased expression of GDF15 mRNAPMID:15205334 PMID:25529476 PMID:26537877 PMID:28940058 PMID:29803840 PMID:30031762
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