GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | PDYN | increases response to substance | EXP | | 6480464 | CTD | PDYN promoter polymorphism results in increased susceptibility to Methamphetamine | PMID:16529859 | PDYN | decreases expression | ISO | Pdyn (Mus musculus) | 6480464 | CTD | Methamphetamine results in decreased expression of PDYN mRNA; Methamphetamine results in decreased expression of PDYN protein | PMID:29467000 | PDYN | increases expression | ISO | Pdyn (Rattus norvegicus) | 6480464 | CTD | Methamphetamine results in increased expression of PDYN mRNA | PMID:20298714 | PDYN | increases response to substance | ISO | Pdyn (Mus musculus) | 6480464 | CTD | PDYN gene mutant form results in increased susceptibility to Methamphetamine | PMID:29467000 | PDYN | multiple interactions | ISO | Pdyn (Rattus norvegicus) | 6480464 | CTD | CTAP octapeptide inhibits the reaction [Methamphetamine results in increased expression of PDYN mRNA] | PMID:20298714 | PDYN | multiple interactions | ISO | Pdyn (Mus musculus) | 6480464 | CTD | 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [[PDYN gene mutant form results in increased susceptibility to Methamphetamine] which results in increased expression of GFAP protein]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]]; 3-((3,5-bis(trifluoromethyl)phenyl)methyloxy)-2-phenylpiperidine inhibits the reaction [PDYN gene mutant form results in increased susceptibility to Methamphetamine]; [PDYN gene mutant form results in increased susceptibility to Methamphetamine] which results in increased expression of GFAP protein; ginsenoside Re inhibits the reaction [Methamphetamine results in decreased expression of PDYN mRNA]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]; ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]]]; norbinaltorphimine inhibits the reaction [ginsenoside Re inhibits the reaction [PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]]]; PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]; PDYN gene mutant form promotes the reaction [Methamphetamine results in decreased expression of TH protein]; PDYN gene mutant form promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of AIF1 protein]; PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of BAX protein]; PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of TAC1 mRNA]; PDYN gene mutant form promotes the reaction [Methamphetamine results in increased expression of TAC1 protein modified form] | PMID:29467000 | | ||||||||||||||||||||||
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