Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1343759
Species: Homo sapiens
RGD Object: Gene
Symbol: CXCL1
Name: C-X-C motif chemokine ligand 1
Acc ID: CHEBI:53001
Term: nickel sulfate
Definition: A metal sulfate having nickel(2+) as the metal ion.
Chemical ID: MESH:C029938
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
CXCL1increases expressionEXP 6480464CTDnickel sulfate results in increased expression of CXCL1 mRNAPMID:16780908 PMID:18832182
CXCL1multiple interactionsEXP 6480464CTDHIF1A protein promotes the reaction [[macrophage stimulatory lipopeptide 2 co-treated with nickel sulfate] results in increased secretion of CXCL1 protein]; macrophage stimulatory lipopeptide 2 promotes the reaction [nickel sulfate results in increased expression of CXCL1 mRNA]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased expression of CXCL1 mRNA]; nickel sulfate promotes the reaction [macrophage stimulatory lipopeptide 2 results in increased secretion of CXCL1 protein]; PTGS2 protein promotes the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of CXCL1 protein]PMID:18832182
CXCL1increases expressionISOCxcl3 (Mus musculus)6480464CTDnickel sulfate results in increased expression of CXCL1 mRNAPMID:16166746
Go Back to source page   Continue to Ontology report