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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1343639
Species: Homo sapiens
RGD Object: Gene
Symbol: PTPN1
Name: protein tyrosine phosphatase non-receptor type 1
Acc ID: CHEBI:27881
Term: resveratrol
Definition: A stilbenol that is stilbene in which the phenyl groups are substituted at positions 3, 5, and 4' by hydroxy groups.
Chemical ID: MESH:C059514
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PTPN1multiple interactionsEXP 6480464CTDNFE2L2 protein affects the reaction [resveratrol inhibits the reaction [Pyruvaldehyde results in increased expression of PTPN1 protein]]PMID:22917016
PTPN1increases expressionISOPtpn1 (Mus musculus)6480464CTDresveratrol results in increased expression of PTPN1 proteinPMID:25505154
PTPN1increases response to substanceISOPtpn1 (Mus musculus)6480464CTDPTPN1 protein results in increased susceptibility to resveratrolPMID:20026400
PTPN1multiple interactionsISOPtpn1 (Mus musculus)6480464CTDresveratrol inhibits the reaction [IRS2 gene mutant form results in increased activity of PTPN1 protein]; resveratrol inhibits the reaction [IRS2 gene mutant form results in increased expression of PTPN1 mRNA]; resveratrol inhibits the reaction [IRS2 gene mutant form results in increased expression of PTPN1 protein]; resveratrol inhibits the reaction [Streptozocin results in increased expression of PTPN1 protein]PMID:20028942 PMID:25808216
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