GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | CIP2A | decreases expression | EXP | | 6480464 | CTD | temsirolimus results in decreased expression of CIP2A mRNA | PMID:24493623 | CIP2A | multiple interactions | EXP | | 6480464 | CTD | Chloroquine inhibits the reaction [temsirolimus results in decreased expression of CIP2A protein]; CIP2A protein results in decreased susceptibility to [Antineoplastic Agents, Immunological co-treated with temsirolimus]; KRAS protein mutant form inhibits the reaction [temsirolimus inhibits the reaction [CIP2A protein binds to MTOR protein]]; leupeptin inhibits the reaction [temsirolimus results in decreased expression of CIP2A protein]; temsirolimus inhibits the reaction [CIP2A protein binds to MTOR protein]; temsirolimus results in decreased expression of and results in increased degradation of CIP2A protein | PMID:24493623 | | ||||||||||||||||||||||
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