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RGD ID: 1343305
Species: Homo sapiens
RGD Object: Gene
Symbol: FBXO27
Name: F-box protein 27
Acc ID: GO:0019005
Term: SCF ubiquitin ligase complex
Definition: A ubiquitin ligase complex in which a cullin from the Cul1 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 adaptor and an F-box protein. SCF complexes are involved in targeting proteins for degradation by the proteasome. The best characterized complexes are those from yeast and mammals (with core subunits named Cdc53/Cul1, Rbx1/Hrt1/Roc1).
Definition Source(s): PMID:15571813, PMID:15688063
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
FBXO27 IBAMGI:MGI:1354743, MGI:MGI:2446216, PANTHER:PTN000252369, UniProtKB:Q8NI29, UniProtKB:Q96EF6, UniProtKB:Q9H4M3, UniProtKB:Q9NRD12290271GO_Central (PMID:21873635)

FBXO27 IDA 2290271UniProtKB (PMID:18203720)

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.