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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1343025
Species: Homo sapiens
RGD Object: Gene
Symbol: MT-CO1
Name: mitochondrially encoded cytochrome c oxidase I
Acc ID: CHEBI:10110
Term: zidovudine
Definition: A pyrimidine 2',3'-dideoxyribonucleoside compound having a 3'-azido substituent and thymine as the nucleobase.
Chemical ID: MESH:D015215
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
MT-CO1decreases expressionISOMt-co1 (Rattus norvegicus)6480464CTDZidovudine results in decreased expression of COX1 proteinPMID:29594326
MT-CO1decreases expressionISOmt-Co1 (Mus musculus)6480464CTDZidovudine results in decreased expression of COX1 proteinPMID:18163507 PMID:20032772
MT-CO1increases expressionISOmt-Co1 (Mus musculus)6480464CTDZidovudine results in increased expression of COX1 mRNAPMID:7528833
MT-CO1multiple interactionsISOmt-Co1 (Mus musculus)6480464CTD[Zidovudine co-treated with Lamivudine] results in decreased expression of COX1 mRNA; Uridine inhibits the reaction [Zidovudine results in decreased expression of COX1 protein]PMID:17526437 PMID:18163507 PMID:18313992 PMID:20032772
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