Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models   new Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources

GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342971
Species: Homo sapiens
RGD Object: Gene
Symbol: ACSL1
Name: acyl-CoA synthetase long chain family member 1
Acc ID: CHEBI:28119
Term: 2,3,7,8-tetrachlorodibenzodioxine
Definition: A polychlorinated dibenzodioxine that has formula C12H4Cl4O2.
Chemical ID: MESH:D013749
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
ACSL1decreases expressionEXP 6480464CTDTetrachlorodibenzodioxin results in decreased expression of ACSL1 mRNAPMID:20106945 PMID:21632981 PMID:26238291
ACSL1multiple interactionsEXP 6480464CTDTetrachlorodibenzodioxin promotes the reaction [AHR protein binds to ACSL1 gene]PMID:28681081
ACSL1affects expressionISOAcsl1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin affects the expression of ACSL1 mRNAPMID:21570461
ACSL1decreases expressionISOAcsl1 (Rattus norvegicus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ACSL1 mRNAPMID:18796159 PMID:21215274
ACSL1decreases expressionISOAcsl1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in decreased expression of ACSL1 mRNAPMID:19770486 PMID:22539624 PMID:28238261
ACSL1increases expressionISOAcsl1 (Mus musculus)6480464CTDTetrachlorodibenzodioxin results in increased expression of ACSL1 mRNAPMID:17035482
ACSL1multiple interactionsISOAcsl1 (Mus musculus)6480464CTD[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in decreased expression of ACSL1 mRNA; Tetrachlorodibenzodioxin inhibits the reaction [[Dexamethasone co-treated with rosiglitazone co-treated with 1-Methyl-3-isobutylxanthine co-treated with INS1 protein] results in increased expression of ACSL1 mRNA]PMID:16054899 PMID:17942748
Go Back to source page   Continue to Ontology report