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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342674
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARGC1A
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:50686
Term: atorvastatin calcium
Definition: An organic calcium salt composed of calcium cations and atorvastatin anions in a 1:2 ratio.
Chemical ID: MESH:D000069059
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGC1Aaffects expressionISOPpargc1a (Mus musculus)6480464CTDAtorvastatin affects the expression of PPARGC1A mRNAPMID:30511338
PPARGC1Adecreases expressionISOPpargc1a (Mus musculus)6480464CTDAtorvastatin results in decreased expression of PPARGC1A proteinPMID:30511338
PPARGC1Adecreases expressionISOPpargc1a (Rattus norvegicus)6480464CTDAtorvastatin results in decreased expression of PPARGC1A mRNAPMID:21775390
PPARGC1Aincreases expressionISOPpargc1a (Rattus norvegicus)6480464CTDAtorvastatin results in increased expression of PPARGC1A mRNAPMID:21775390
PPARGC1Amultiple interactionsISOPpargc1a (Mus musculus)6480464CTD[PPARGC1B protein affects the susceptibility to Atorvastatin] which affects the expression of PPARGC1A mRNAPMID:30511338
PPARGC1Amultiple interactionsISOPpargc1a (Rattus norvegicus)6480464CTD[Atorvastatin co-treated with dapagliflozin] inhibits the reaction [[Fructose co-treated with Dietary Fats] results in decreased expression of PPARGC1A protein]; Acetylcysteine inhibits the reaction [Atorvastatin results in increased expression of PPARGC1A mRNA]; Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]; Farnesol inhibits the reaction [Atorvastatin inhibits the reaction [TNF protein results in decreased expression of PPARGC1A protein]]PMID:21775390 PMID:22343369 PMID:32259528
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