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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1342674
Species: Homo sapiens
RGD Object: Gene
Symbol: PPARGC1A
Name: PPARG coactivator 1 alpha
Acc ID: CHEBI:50648
Term: 9-cis-retinoic acid
Definition: A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.
Chemical ID: MESH:C103303
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PPARGC1Aincreases expressionEXP 6480464CTDAlitretinoin results in increased expression of PPARGC1A mRNAPMID:16513826
PPARGC1Aincreases expressionISOPpargc1a (Mus musculus)6480464CTDAlitretinoin results in increased expression of PPARGC1A mRNAPMID:16513826
PPARGC1Amultiple interactionsISOPpargc1a (Mus musculus)6480464CTD2-chloro-5-nitrobenzanilide inhibits the reaction [Alitretinoin results in increased expression of PPARGC1A mRNA]; PPARG protein promotes the reaction [Alitretinoin results in increased expression of PPARGC1A mRNA]; RXRA protein promotes the reaction [Alitretinoin results in increased expression of PPARGC1A mRNA]PMID:16513826
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