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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332548
Species: Mus musculus
RGD Object: Gene
Symbol: Ppargc1a
Name: peroxisome proliferative activated receptor, gamma, coactivator 1 alpha
Acc ID: CHEBI:35456
Term: cadmium dichloride
Definition: A cadmium coordination entity in which cadmium(2+) and Cl(-) ions are present in the ratio 2:1. Although considered to be ionic, it has considerable covalent character to its bonding.
Chemical ID: MESH:D019256
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ppargc1adecreases expressionISOPpargc1a (Rattus norvegicus)6480464CTDCadmium Chloride results in decreased expression of PPARGC1A mRNA; Cadmium Chloride results in decreased expression of PPARGC1A proteinPMID:36493885
Ppargc1aincreases acetylationISOPPARGC1A (Homo sapiens)6480464CTDCadmium Chloride results in increased acetylation of PPARGC1A proteinPMID:25159133
Ppargc1aincreases expressionISOPPARGC1A (Homo sapiens)6480464CTDCadmium Chloride results in increased expression of PPARGC1A proteinPMID:25809595
Ppargc1aincreases methylationISOPpargc1a (Rattus norvegicus)6480464CTDCadmium Chloride results in increased methylation of PPARGC1A promoterPMID:22457795
Ppargc1amultiple interactionsISOPPARGC1A (Homo sapiens)6480464CTD[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of PPARGC1A mRNA; luzindole inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]; Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]; sirtinol inhibits the reaction [Melatonin inhibits the reaction [Cadmium Chloride results in increased acetylation of PPARGC1A protein]]PMID:25159133 PMID:35301059
Ppargc1amultiple interactionsISOPpargc1a (Rattus norvegicus)6480464CTDAcetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PPARGC1A mRNA]; Acetylcysteine inhibits the reaction [Cadmium Chloride results in decreased expression of PPARGC1A protein]; Resveratrol inhibits the reaction [Cadmium Chloride results in decreased expression of PPARGC1A protein]PMID:36493885
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