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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332312
Species: Mus musculus
RGD Object: Gene
Symbol: Xbp1
Name: X-box binding protein 1
Acc ID: CHEBI:6809
Term: methamphetamine
Definition: A member of the class of amphetamines in which the amino group of (S)-amphetamine carries a methyl substituent.
Chemical ID: MESH:D008694
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xbp1increases expressionEXP 6480464CTDMethamphetamine results in increased expression of XBP1 proteinPMID:27323860
Xbp1increases expressionISOXbp1 (Rattus norvegicus)6480464CTDMethamphetamine results in increased expression of XBP1 mRNA; Methamphetamine results in increased expression of XBP1 mRNA alternative form; Methamphetamine results in increased expression of XBP1 protein alternative formPMID:19564919 PMID:28070110 PMID:34214594
Xbp1increases expressionISOXBP1 (Homo sapiens)6480464CTDMethamphetamine results in increased expression of XBP1 mRNA; Methamphetamine results in increased expression of XBP1 proteinPMID:27323860
Xbp1multiple interactionsISOXbp1 (Rattus norvegicus)6480464CTD4-phenylbutyric acid inhibits the reaction [Methamphetamine results in increased expression of XBP1 protein alternative form]; Melatonin inhibits the reaction [Methamphetamine results in increased expression of XBP1 mRNA alternative form]; Methamphetamine results in increased expression of and results in increased splicing of XBP1 mRNA; SCH 23390 inhibits the reaction [Methamphetamine results in increased splicing of XBP1 mRNA]PMID:19564919 PMID:28070110 PMID:34214594
Xbp1multiple interactionsISOXBP1 (Homo sapiens)6480464CTDATF6 protein affects the reaction [Methamphetamine results in increased expression of XBP1 mRNA]; ATF6 protein affects the reaction [Methamphetamine results in increased expression of XBP1 protein]PMID:27323860
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