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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1332312
Species: Mus musculus
RGD Object: Gene
Symbol: Xbp1
Name: X-box binding protein 1
Acc ID: CHEBI:29699
Term: tunicamycin
Definition: A mixture of antiviral nucleoside antibiotics produced by Streptomyces lysosuperificus. It contains at least 10 homologues comprising uracil, N-acetylglucosamine, an 11-carbon aminodialdose called tunicamine, and a fatty acid linked to the amino group of the tunicamine. The homologues vary in the composition of the fatty acid moiety.
Chemical ID: MESH:D014415
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Xbp1increases expressionEXP 6480464CTDTunicamycin results in increased expression of XBP1 mRNA; Tunicamycin results in increased expression of XBP1 mRNA alternative form; Tunicamycin results in increased expression of XBP1 protein alternative formPMID:21321189 PMID:22414386 PMID:22509299 PMID:36030031
Xbp1increases splicingEXP 6480464CTDTunicamycin results in increased splicing of XBP1 mRNAPMID:16330322 PMID:20015086 PMID:20554909 PMID:22001960 PMID:25160872 PMID:25324550 PMID:29380555 PMID:33454823
Xbp1multiple interactionsEXP 6480464CTD[ATG5 protein mutant form results in increased susceptibility to Tunicamycin] which results in increased expression of XBP1 mRNA; [Resveratrol results in decreased activity of MTOR protein] inhibits the reaction [Tunicamycin results in increased expression of XBP1 mRNA alternative form]; Amiloride inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]; Particulate Matter inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]; Tunicamycin inhibits the reaction [mevastatin results in increased cleavage of XBP1 protein]PMID:16330322 PMID:20015086 PMID:20554909 PMID:21321189 PMID:29793971
Xbp1increases expressionISOXbp1 (Rattus norvegicus)6480464CTDTunicamycin results in increased expression of XBP1 proteinPMID:28399139
Xbp1increases expressionISOXBP1 (Homo sapiens)6480464CTDTunicamycin results in increased expression of XBP1 mRNA; Tunicamycin results in increased expression of XBP1 mRNA alternative form; Tunicamycin results in increased expression of XBP1 protein; Tunicamycin results in increased expression of XBP1 protein alternative formPMID:22378314 PMID:22959463 PMID:23741617 PMID:27358234 PMID:29453283 PMID:32407927 PMID:36586010
Xbp1increases splicingISOXbp1 (Rattus norvegicus)6480464CTDTunicamycin results in increased splicing of XBP1 mRNAPMID:18477628 PMID:24291486 PMID:29956773 PMID:32574669
Xbp1increases splicingISOXBP1 (Homo sapiens)6480464CTDTunicamycin results in increased splicing of XBP1 mRNAPMID:19135031 PMID:23741617 PMID:24210820 PMID:31022492 PMID:34560123
Xbp1multiple interactionsISOXbp1 (Rattus norvegicus)6480464CTDibutilide inhibits the reaction [Tunicamycin results in increased expression of XBP1 protein]; Nicotine inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]PMID:18477628 PMID:28399139
Xbp1multiple interactionsISOXBP1 (Homo sapiens)6480464CTDLuteolin inhibits the reaction [Tunicamycin results in increased expression of XBP1 mRNA alternative form]; SIRT7 protein inhibits the reaction [Tunicamycin results in increased splicing of XBP1 mRNA]; Tunicamycin inhibits the reaction [Thapsigargin results in increased expression of XBP1 mRNA]; Tunicamycin results in increased splicing of and results in increased expression of XBP1 mRNA alternative formPMID:17917237 PMID:24210820 PMID:24312631 PMID:32407927
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