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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1331934
Species: Mus musculus
RGD Object: Gene
Symbol: Prom1
Name: prominin 1
Acc ID: CHEBI:27899
Term: cisplatin
Definition: A diamminedichloroplatinum compound in which the two ammine ligands and two chloro ligands are oriented in a cis planar configuration around the central platinum ion. An anticancer drug that interacts with, and forms cross-links between, DNA and proteins, it is used as a neoplasm inhibitor to treat solid tumours, primarily of the testis and ovary. Commonly but incorrectly described as an alkylating agent due to its mechanism of action (but it lacks alkyl groups).
Chemical ID: MESH:D002945
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Prom1decreases expressionISOPROM1 (Homo sapiens)6480464CTDCisplatin results in decreased expression of PROM1 proteinPMID:21788103
Prom1decreases response to substanceISOPROM1 (Homo sapiens)6480464CTDPROM1 results in decreased susceptibility to CisplatinPMID:21919130
Prom1increases expressionISOPROM1 (Homo sapiens)6480464CTDCisplatin results in increased expression of PROM1 proteinPMID:21618587
Prom1multiple interactionsISOPROM1 (Homo sapiens)6480464CTD[Cisplatin co-treated with Paclitaxel] results in increased expression of PROM1 mRNA; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of PROM1 mRNA; [Cisplatin results in decreased susceptibility to Cisplatin] which results in increased expression of PROM1 protein; [NEAT1 protein affects the susceptibility to Cisplatin] which affects the expression of PROM1 proteinPMID:20705681 PMID:21342274 PMID:30291867 PMID:30871063
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