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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1331867
Species: Mus musculus
RGD Object: Gene
Symbol: Scd2
Name: stearoyl-Coenzyme A desaturase 2
Acc ID: CHEBI:2663
Term: amiodarone
Definition: A member of the class of 1-benzofurans that is 1-benzofuran substituted by a butyl group at position 2 and a 4-[2-(diethylamino)ethoxy]-3,5-diiodobenzoyl group at position 3. It is a cardiovascular drug used for the treatment of cardiac dysrhythmias.
Chemical ID: MESH:D000638
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Scd2increases expressionISOSCD (Homo sapiens)6480464CTDAmiodarone results in increased expression of SCD mRNAPMID:21123845 PMID:29248575 PMID:32535746
Scd2multiple interactionsISOSCD (Homo sapiens)6480464CTD[2-chloro-5-nitrobenzanilide results in decreased activity of PPARG protein] inhibits the reaction [Amiodarone results in increased expression of SCD mRNA]; SCD protein affects the reaction [Amiodarone results in increased uptake of 1-acyl-2-(12-((7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)dodecanoyl)phosphatidylcholine]PMID:21123845
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