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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323582
Species: Homo sapiens
RGD Object: Gene
Symbol: TRPM2
Name: transient receptor potential cation channel subfamily M member 2
Acc ID: CHEBI:25434
Term: bis(2-chloroethyl) sulfide
Definition: An ethyl sulfide that is diethyl sulfide in which a hydrogen from each of the terminal methyl groups is replaced by a chlorine. It is a powerful vesicant regulated under the Chemical Weapons Convention.
Chemical ID: MESH:D009151
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
TRPM2affects response to substanceEXP 6480464CTDTRPM2 protein affects the susceptibility to Mustard GasPMID:22036725
TRPM2multiple interactionsEXP 6480464CTD[Clotrimazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium]; [Econazole results in decreased activity of TRPM2 protein] inhibits the reaction [Mustard Gas results in increased abundance of Calcium]; TRPM2 protein affects the reaction [Mustard Gas results in increased abundance of Calcium]PMID:22036725
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