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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1323391
Species: Homo sapiens
RGD Object: Gene
Symbol: PRDM1
Name: PR/SET domain 1
Acc ID: CHEBI:34718
Term: 1-chloro-2,4-dinitrobenzene
Definition: A C-nitro compound that is chlorobenzene carrying a nitro substituent at each of the 2- and 4-positions.
Chemical ID: MESH:D004137
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
PRDM1increases expressionEXP 6480464CTDDinitrochlorobenzene results in increased expression of PRDM1 mRNA; Dinitrochlorobenzene results in increased expression of PRDM1 proteinPMID:27585668 PMID:31276767
PRDM1multiple interactionsEXP 6480464CTDBAY 11-7085 inhibits the reaction [Dinitrochlorobenzene results in increased expression of PRDM1 mRNA]; BAY 11-7085 inhibits the reaction [Dinitrochlorobenzene results in increased expression of PRDM1 protein]; PRDM1 protein promotes the reaction [Dinitrochlorobenzene results in increased expression of IL18 protein]PMID:27585668 PMID:31276767
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